HYPOLIPIDEMIC EFFECT OF CALOTROPIS GIGANTEA SEEDS EXTRACT ON HIGH FAT DIET INDUCED ATHEROGENIC RATS
Jatin Jaiswal *, Hemant Bhardwaj, Dr. Ch. V. Rao, Nisha Sharma
ABSTRACT
Objective: The present study was designed to evaluate the
hypolipidemic activity of Calotropis gigantea seeds on high fat diet
induced atherogenic rats. Methods: The acute toxicity studies were
performed on mice while adopting the OECD-420 Guidelines (fixed
dose procedure). The hypolipidemic effect of plant seed extracts was
evaluated on the standard 28 days model. Results: Treatment with
methanolic extract of Calotropis gigantea (MECG) seeds at the dose
200 mg/kg and 400 mg/kg body weight showed the significant
decrease in the total cholesterol levels, triglycerides levels, VLDL-c
and LDL-c levels, whereas there was slight increase in HDL-c levels.The activities were also
compared with the effects produced by the standard anti-hyperlipidemic drug, atorvastatin 10
mg/kg. Conclusion: The present findings indicate that the seeds of Calotropis gigantea has a
potent hypolipidemic effect on HFD induced atherogenic rats.
Keywords: Madar, Calotropis gigantea, OECD, MECG, streptozotocin and glimipride
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