Abstract

SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) ALTERNATIVE APPROACH TO IMPROVE ORAL BIOAVAILABILITY OF LIPOPHILIC DRUGS

*Tarun Parashar and Soniya

ABSTRACT

The most popular route of administration is oral route in many diseases. Major problem in oral route of drug administration is decreased bioavailability which mainly results from poor aqueous solubility. For better therapeutic response, solubility is one of the most important parameter to achieve desired concentration of drug in systemic circulation. Poor solubility of drug in systemic circulation leads to problems in dose uniformity. It is found that most of the active substances are poorly water-soluble. In Self micro emulsifying drug delivery systems drug is encapsulated in a lipid base with or without pharmaceutical acceptable surfactant. Self micro emulsifying drug delivery systems are isotropic mixture of oil, surfactant, and co- surfactant and are vital tool in solving low bioavailability issue of poorly soluble drug. Lipophilic drugs can be dissolved in that system, enabling them to be administered as a unit dosage form for per oral administration. SMEDDS will continue to enable novel applications in drug delivery and solve problems associated with the delivery of poorly soluble drugs.

Keywords: SMEDDS, Bioavailability, Poorly solubility, oral route, surfactants.