Abstract

PHARMACEUTICAL NANOSUSPENSION: AN OVERVIEW

Nimmi R.*, Shripathy D. and Shabaraya A. R.

ABSTRACT

Nanosuspensions, a form of this technology, have proven their value in the medical field. Nanosuspension technology was used to make drugs that were poorly soluble in aqueous as well as inorganic media visible. Nanosuspensions have proved to be a safer alternative to other currently available methods for increasing bioavailability of low-solubility drugs. Nanosuspension is characterised as very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1um, without any matrix content, stabilised by surfactants and polymers, prepared by suitable methods for Drug Delivery applications, through oral, topical, parenteral, ocular, and pulmonary routes. Wet mill, high pressure homogenizer, precipitation- ultrasonication process, emulsionsolvent evaporation, melt emulsification method, and supercritical fluid extraction method are also used to make nanosuspensions. The following work focuses on the preparation of nanosuspensions, as well as the benefits of such methods, and their applications, in the hopes of simplifying future research in this field.

Keywords: Nanosuspension, solubility, Bioavailability, High pressure homogenizer, Precipitation- ultrasonication, Super critical fluid extraction, Emulsion-solvent extraction.