Abstract

THERAPEUTIC EFFECTS OF ZANTHOXYLUM TETRASPERMUM W.A. STEM BARK ON CARBOHYDRATE METABOLIZING ENZYMES IN MAMMARY CARCINOMA MICE

Mr.Narayanasamy K.* and Dr.Ragavan B

ABSTRACT

Mammary carcinoma is a heterogeneous disease that appears to progress from an in situ tumor to invasive cancer. Little is known about the molecular events driving this progression. The genus Zanthoxylum is known as “Timoor” that is used as mouth fresh, tooth care and spice. Zanthoxylum tetraspermum (Wight & Arn.) belongs to the family“Rutaceae” possesses some biological activities. The present study evaluated the effect of Z.tetraspermum stem bark extract (300 and 600mg / kg body weight) in liver and kidney of N-methyl-Nnitrosourea (MNU) induced mammary carcinoma mice on carbohydrate metabolizing enzymes and pentose phosphate pathway enzyme. Mammary carcinoma-bearing mice showed a significant (P

Keywords: (5-FU) as positive drug control group showed no significant variations in enzyme activities. The results obtained in the present study indicate the therapeutic effect of the stem bark extract and validates the traditional use of this plant in mammary carc