Abstract

COVID-19 PROGNOSIS IN HIV-POSITIVE PATIENTS

Antonio Neres Norberg*, Paulo Roberto Blanco Moreira Norberg, Fabiano Guerra Sanches, Fernanda Castro Manhães, Paulo Cesar Ribeiro, Alcemar Antônio Lopes de Matos and Bianca Magnelli Mangiavacchi

ABSTRACT

AIDS and COVID-19 are epidemically evolving viruses with complex clinical features. Although the HIV and the syndrome that characterizes this virus infection are currently well known, the emerging of a new pandemic of the SARS-CoV-2, with an acute course and diverse clinical presentations, brings a new challenge to health professionals regarding the possibilities of the synergy between these two pathogens. The present manuscript aims to evaluate some answers to these questions through the analysis of clinical experiences available in current scientific literature, to elucidate the possible synergistic effects between concomitant HIV and SARS-CoV-2 infections and the prognosis of these patients. Regarding possible interactions between HIV and SARS-CoV-2 infections, the scientific literature still does not point to an objective definition regarding the prognosis of patients presenting with this coinfection. However, the clinical experiences so far verified suggest that some important aspects in the evaluation of the clinical course of this group of patients have an impact on the prognosis of the infection caused by COVID-19. Beyond the complexity of the interaction between COVID-19 and AIDS, the analysis of this coinfection must be done through a much broader approach, considering the syndemic aspects of both viruses and the amplitude of social, environmental, behavioural and health-related factors of each group studied, whose impact is directly related to the prognoses of the evolution of the patients' health status.

Keywords: COVID-19, SARS-CoV-2, HIV, AIDS, Coinfection.