Abstract

FORMULATION AND EVALUATION OF HERBAL ANTIFUNGAL CREAM OF PHYLLANTHUS URINARIA

Sohel I. Nadaf*, Nikita D. Gidde, Priyanka V. Desai, Priyanka V. Bagade, Mayuri S. Lokhande and Dinesh S. Mavinmar

ABSTRACT

Phyllanthus urinaria leaves extract is well known by its antifungal activity and its uses in skin diseases. The goal of this study was to see if an aqueous extract of the plant leaves had antifungal activity against Candida albicans and Escherichia coli. In addition, to develop an effective, long-lasting herbal antifungal cream and examine its physical and antifungal properties. The antifungal activity of a leaf extracts was assessed using the disc diffusion technique with antibiotic reference discs. The antifungal cream was prepared by mixing various amounts of ingredients as well as a small amount of herbal extract. Physical and antifungal properties of the prepared cream were examined. The antifungal activity of the aqueous extract was found to be effective against both candida albicans lococcus and E. coli especially when the extract concentration increased. It can be concluded that the aqueous extract of Phyllanthus urinaria leaves exhibited strong antifungal activity especially with increase of the extract concentration. The cream that was produced was proven to be natural, stable, and safe. Skin infection may be treated with Phyllanthus urinaria cream applied topically. The Present investigation suggests that this cream is a suitable candidate for further clinical trials.

Keywords: Phyllanthus urinaria; aqueous extract; Antifungal cream; Herbal; candida albicans lococcus; E.Coli.