Abstract

EFFICACY OF MONOTHERAPY AND COMBINATION THERAPY IN HYPERTENSIVE PATIENTS: A COMPARATIVE STUDY

Sadaram Samba Shiva*, Donaka Pujita, Pvrkghh Nandan and Surada Ramya

ABSTRACT

Background: Identifying the most effective antihypertensive drugs/combinations which will improve the management of hypertensive patients. Aim and objectives: To compare the efficacy of antihypertensive drugs when given in monotherapy and combination therapy to assess the blood pressure (BP) reductions. Measures and outcomes: Mean decrease in SBP and DBP. Methods and materials: Demographic and baseline characteristics were summarized using descriptive statistics. BP recordings of the patients were collected and their mean, standard deviation values were calculated. Comparisons of categoric data were made using the Mood's median test. Comparison among groups was performed using point-biserial correlation coefficient test. The drugs given in monotherapy were Losartan, Amlodipine, Valsartan, Hydrochlorothiazide and in combination therapy were Losartan/ Hydrochlorothiazide, Losartan/Amlodipine, Amlodipine/Telmisartan, Valsartan/ Hydrochlorothiazide. Results: Valsartan/ Hydrochlorothiazide combination showed to be more effective. Conclusion: Combination therapy was more effective in treating hypertension than monotherapy.

Keywords: Antihypertensive drugs, Combination therapy, Diastolic blood pressure, Monotherapy, Systolic blood pressure.