Abstract

PHARMACOGNOSTIC AND PHYTOCHEMICAL ANALYSIS OF OXALIS LATIFOLIA KUNTH AND THEIR ANTIULCER ACTIVITY ON ALBINO RATS

Hari Bhaskar and Kothapalli Bannoth Chandra Sekhar

ABSTRACT

The objective of the present study was to evaluate the pharmacognostic, phytochemical analysis and antiulcer potential of methanol extracts of Oxalis latifolia kunth in different experimental induced ulcer models in rats. In the present study different extracts, methanol (200 mg/kg and 400 mg/kg) extract of leaves of the plant were examined in Pylorus ligation and Indomethacin induced gastric ulcer in rats. Various parameters like volume of gastric acid secretion, pH, total acidity, ulcer index and antioxidant parameters were determined and compared between extract treated, standard and vehicle control group animals following ulcer induction. Among different dose of alcoholic extract, high dose showed significant antiulcer activity in Pylorus ligation and Indomethacin induced ulceration. The result of present study concluded that the alcoholic extract of leaves of the plant of Oxalis latifolia kunth has antiulcer activity in Pylorus ligation and Indomethacin induced gastric ulcer model in rats. The extract containing flavonoidal component latifolin A is as luteolin-6′′-(E-p-hydroxycinnamoyl) 4′-O-β-D-glucopyranoside is isolated, analysed by various spectral analysis and formulated as a capsule. This latifolin A capsule is main responsible for the anti ulcer activity.

Keywords: Pylorus ligation, Indomethacin, Total acidity, Latifolin A, Oxalis latifolia etc.