Abstract

SELF-EMULSIFYING DRUG DELIVERY SYSTEM: A NOVEL APPROACH

M. Gandhi* and Dr. D. A. Chavda

ABSTRACT

Nowadays, a large number of research followed in pharmaceuticals field but the mainly problem arises due to the 35-40% of drugs have poor aqueous solubility problem. This lead various of interlink problems like low bioavailability, inter or intra variability issues etc. There are several of techniques used by the scientist to resolve this problem. Eg. Formulation of solid dispersion, by forms Salt of the molecule etc. SEDDS is the newer approach widely used to improve the solubility of lipophilic drugs. SEDDS are the isotropic mixtures of oils, surfactants, solvents and co-solvents. The micro or nano- size provide the benefit to easily pass through the lymphatic side and bypass the hepatic circulation and also improve the absorption at the gastro intestinal site. We exhausted the updated outcomes of following articles and patents to represent the mechanism of work by self emulsification method, The advantages of SMEDDS over conventional emulsions are listed, optimization technique discussion like making of pseudo-ternary phase digram, Characterization techniques and marketed patent preparations.

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