Abstract

SYNTHESIS, CHARACTERIZATION, IN VIVO ANTI-DIABETIC ACTIVITY A COUMARIN DERIVATIVES

Fawzia Z. El-Ablack*, Faten Z. Mohamed, Usama B. Elgazzar and Mahmoud M. Ramzy

ABSTRACT

Background: Diabetes mellitus (DM) is a group of metabolic disorders characterized by chronic hyperglycemia resulting from relative or absolute insulin deficiency with or without insulin resistance. Aim: This study was aimed to evaluate the role of new coumarin derivative (cromen) in treatment of alloxan induced diabetes in rats by. Methods: 50 adult male albino rats were divided into 5 groups. Group I (control group, rats were orally administered with 1 ml saline daily). Group II (DMSO group, rats were orally administered with 0.2 % DMSO for 40 days). Group III (standard group, diabetic animals treated with 100 mg/kg b.wt of metformin for 40 days orally). Group IV (therapeutic group, diabetic rats treated orally with 50 mg/kg b.wt of cromen for 40 days). Group V (positive control, animals were injected intraperitoneal with 150 mg/kg b. wt. alloxan). At the end of experimental period blood serum, liver, kidney and pancreatic tissues were collected. Results: diabetic rats showed significant increase in the mean level of blood Glucose, serum ALT, AST, Total bilirubin, Urea, Creatinine, Cholesterol and triglyceride. Also, significant decrease in ALB level in compared to control group. In group treated with cromen there was significant decrease in elevated biochemical parameters. Also, significant increase ALB level when compared with diabetic rats. Our results were confirmed by histopathological examination of different tissues. Conclusion: this study suggests that cromen exhibits anti-hyperglycemic and anti-lipidimic in alloxan induced diabetic rats.

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