Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF RITONAVIR

Kunal. J. Patil* Dr. Surajj M. Sarode, Prof. Bhushankumar S. Sathe, Dr. Parag V. Jain, Bharat V. Jain

ABSTRACT

The present investigation an attempt have been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance, by developing sustained release matrix tablets of Ritonavir. Sustained release matrix tablets of ritonavir were developed by using different polymer like Hydroxyl Propyl Methyl Cellulose (K100M), Eudragit RS 100, Chitosan, in different ratio formulations were compressed by wet granulation method. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, invitro dissolution. The in vitro drug release characteristics were studied in both simulated gastric and intestinal fluids for a period of 12 hr using USP Type 2 dissolution apparatus. Drug in combination with chitosan were found to be effective in retarding the release of Ritonavir.

Keywords: Sustained release, Ritonavir, HPMC K100M, Chitosan, Eudragit RS100.