Abstract

ANXIOLYTIC EVALUATION OF HIBISCUS ROSA SINENSIS LEAVES EXTRACTS IN MICE

Abhishek*, Maninder Kaur, Ajeet Pal Singh and Amar Pal Singh

ABSTRACT

Anxiety is one of the most common mental disorders, characterized by changes in mood, behavior, somatic function and cognition. There are five major types of anxiety disorders. Benzodiazepines and SSRIs are most commonly employed drugs for the treatment of anxiety. Synthetic drugs available for treatment of anxiety have various adverse effects. Drugs obtained from natural sources are known to cause fewer side effects compared to synthetic drugs despite of same ability to cure disease. Hibiscus rosa sinensis belongs to Malvaceae family, well known ancient ayurvedic medicinal tree commonly known as the China rose was used for the study. Aqueous and ethanolic extract of Hibiscus rosa sinensis (250mg/kg, 500mg/kg), diazepam 1mg/kg are administered orally. Anxiolytic activity is assessed by Elevated Plus Maze (EPM) and Light Dark Model (LDM) for locomotor activity. Blood samples were also collected for the biochemical estimation for the Plasma corticosterone levels. They had showed the significant results for both anxiety parameters and biochemical estimation.

Keywords: Hibiscus rosa sinensis, Anxiolytic, corticosterone levels, LDM – Light Dark Model, EPM – Elevated Plus Maze.