Abstract

A PROSPECTIVE STUDY ON IMPACT OF CLINICAL PHARMACIST INTERVENTION IN MANAGEMENT OF PATIENTS WITH CARDIOVASCULAR DISEASES/DISORDERS IN ACHIEVEMENT OF DESIRED THERAPEUTIC OUTCOME AND PROMOTION OF RATIONAL DRUG USAGE

Shahin Mojra*, Mekkanti Manasa Rekha and Rinku Mathappan

ABSTRACT

Cardiovascular diseases (CVDs) remain the biggest cause of deaths worldwide. AWHO reports. (2012) estimated that 17.5 million people die of CVDs each year representing 31% of all deaths. Although pharmacotherapy in cardiovascular diseases can improve the well-being, its benefit can be compromised by drug-related problems (DRPs). A drug-related problem is any event or circumstance involving drug treatment that interferes with the patient achieving an optimum outcome of medical care. Aim: The present aims at studying the impact of clinical pharmacist interventions in management of patients with cardiovascular diseases/ disorders in achievement of desired therapeutic outcomes and promotion of rational drug usage. Objectives: Primary: To Identification, Reporting and Minimization of Drug Related Problems like ADR’s, Drug interactions and Incorrect drug dosage, Secondary: To identify pattern of drug-drug interactions in cardiac patients and documenting clinical effects of these interactions, ADRs to evaluate risk factors and demographic of patients and correlate it with drug -drug interaction, to assess pharmacist specific intervention in preventing and minimizing drug interactions and Improving the quality of life of patients. Methodology: The Present Study was a Prospective Interventional study conducted over a Minimum period 6 months from October 2019 to March 2020 in Cardiology and General Medicine Departments in ESI Hospital, Indiranagar, Bangalore, Karnataka, Inclusion Criteria:All cardiac patients admitted in cardiac ward, Patients who were taking at least two drugs and had a hospital stay of at least 48 hours. Exclusion Criteria: Patients admitted to Pediatric and Obstetric and pregnancy ward Statistical Analysis: Microsoft excel is used for recording and analyzing the data of recruited subjects and calculating Mean, Standard Deviation etc. Descriptive Statistics and Prism Graph Software will be used for the study to calculate P –Value to state the level of significance. Results and Discussion: The Data of 220 patients admitted to inpatients ward during the period. October 2019 to march 2020 was analyzed for assessment of potential drug interaction. Among them 140 patients had at least one potential drug interactions. The mean age of study population was 64.43 (±14.58) year. Out of 220 prescriptions analyzed, as 140 prescriptions comprised of potential drug interactions and it was found that 234 drug interactions were present. The incidence of potential drug interaction was 63.64%, A total of 28 adverse drug reactions were recorded among 234 PDDI, the incidence rate of adverse drug interaction was found to be 20%. 234 interventions proposed out of that 25.64% were accepted and therapy changed, out of 220 patient 16 incorrect dose detected which is 7.2 case per 100 patients (7.2%).Conclusion: The present Study attempted in assessing and reporting the impact of Clinical Pharmacist Interventions such as potential drug-drug interaction, adverse drug reactions, dose modifications and dose adjustments in the management of cardiac patients in inpatient hospital setting.

Keywords: doctor of pharmacy, drug related problems, prism graph pad software, cardiology medicine department, cardiovascular diseases