Abstract

A REVIEW: TOPICAL INSULIN ON WOUND HEALING

Shweta Pawar*, Utkarsha Gavhane, Aarti Nangare, Sujit Kakade and Ashok Bhosale

ABSTRACT

Wound healing is a complex biological process that repairs damaged tissues and restores skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies. Although wound healing mechanisms and specific cell functions in wound repair have been delineated in part, many underlying pathophysiological processes are still unknown. The purpose of the following update on skin wound healing is to focus on the different phases and to brief the reader on the current knowledge and new insights. Skin wound healing is a complex process, which is dependent on many cell types and mediators interacting in a highly sophisticated temporal sequence. Although some interactions during the healing process are crucial, redundancy is high and other cells or mediators can adopt functions or signaling without major complications. Thus, this study aimed to review evidence of the effects of topical insulin on wound healing, including on diabetic and non-diabetic wounds., topical insulin has been appreciated in field of wound healing, and further studies are needed to improve our understanding of the role of insulin in the healing of various wounds.

Keywords: Wound healing, Topical insulin, Mechanism, Inflammation.