Abstract

REVIEW ON LOCAL DRUG DELIVERY SYSTEMS FOR PERIODONTITIS

Kirshnananda Kamath K.*, A. R. Shabaraya and Mithun Kumar

ABSTRACT

Antibacterial agents have been used successfully in the management of periodontal infection. Periodontal infections are resulting in localized inflammatory response caused by bacterial infection of a periodontal pocket associated with sub-gingival plaque. The effectiveness of mechanical debridement of plaque and repeated topical and systemic administration of antibacterial agents are limited due to the lack of accessibility to periodontal pathogens. Various antibacterial agents have been used effectively in the management of periodontal infection. Local application into periodontal pocket could be very advantageous, both in terms of drug concentration directly site at the action, and in preventing systemic side effects such as gastrointestinal complaints, depression, and tachycardia. Controlled delivery of chemotherapeutic agents within periodontal pockets can alter the pathogenic flora and improve clinical signs of periodontitis. Local drug delivery systems provide several benefits; the drug can be delivered to the site of disease activity at a bactericidal concentration and it can facilitate prolonged drug delivery. Now days the use of sustained release formulations which delivers antibacterials locally to the site of infection is gaining interest. This ultimately reduces the dosing frequency, thereby increasing patient compliance. This review approaches the mainly Local delivery systems for the treatment of periodontal pocket, their usefulness.

Keywords: Periodontitis, Antibacterial agents, systemic administration, periodontal pathogens, Patient compliance.