Abstract

REVIEW ON BORON NEUTRON CAPTURE THERAPY

*Sandhya M. J. Nair, Hima C. S., Nisha V. T., Aswany U. R. and Bismi S.

ABSTRACT

Boron neutron capture therapy (BNCT) is a non-invasive therapeutic technique for treating invasive malignant tumours. It is based on the nuclear reaction that occurs when boron-10 is irradiated with low energy thermal neutrons or higher energy epithermal neutrons. BNCT has been evaluated clinically as an alternative to conventional radiation therapy for the treatment of high-grade gliomas, meningiomas, and recurrent, locally advanced cancers of the head and neck region and superficial cutaneous and extra cutaneous melanomas.this review highlights the principle of BNCT, boron delivery agents, neutron sources and accelerators are described.

Keywords: Accelerator-based neutron sources, 10Boron, Linear energy transfer, Massachusetts Institute of Technology Reactor, Neutron capture therapy, Relative biological effectiveness.