Abstract

RECENT ADVANCES AND ISSUES IN CANCER MANAGEMENT AND THERAPY: A REVIEW

Richard Owusu Nyarko, Ivan Kahwa, Paul Owusu Boateng, Amit Prakash, Shrestha Sarkar, Purabi Saha and *Roshan Kumar

ABSTRACT

Nanotechnology has the ability, by using traditional therapeutic formulations, to avoid some drawbacks. In fact, substantial steps have been taken towards the use of engineered nanomaterials for cancer treatment that are highly precise, sensitive and efficient. Custom-made nanomaterials with certain ligands can predictably target cancer cells and effectively carry encapsulated payloads. Nanomaterials can also be engineered for increased loading of drugs, enhanced body half-life, controlled release and selective distribution by adjusting the structure, dimensions, morphology and chemistry of the surface. To date, polymeric nanomaterials, metal nanoparticles, carbon based compounds, liposomes and dendrimers have been engineered as intelligent cancer deliveries to improved pharmacokinetic and pharmacodynamic profiles in nanoscale and special physiochemical characteristics in comparison to traditional formulations. The literature suggests that nanotechnology can provide platforms for the next generation of the treatment and therapy of cancer. In this important study, we therefore review a number of nanomaterials commonly used to treat anticancer and investigate their fundamental role in the management of cancer. We explore more current advances in cancer engineering, including existing drug targeting techniques and releasing for efficient cancer administration in the field of nanomaterial engineering. We often speak about problems related to nanotoxicity, which in nanotechnology is often ignored. Finally, we are trying to summarize the current nanotherapeutic problems and give a perspective on the future of this critical field.

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