Abstract

TOXICITY OF SILVER NANOPARTICLES, IRON OXIDE NANOPARTICLES, AND THEIR MIXTURE ON CYTOKINES IN TESTES OF MALE RATS

Ahmed Ibrahim Younus*, Mokhtar Ibrahim Yousef, Maher Abdel-Nabi Kamel, Rakhad Alrawi and Jubran Mohammed Abdulrahman

ABSTRACT

In the present study Wistar male rats were used. Animals were divided into 4 equal groups, 10 rats each. Group 1 served as control, group 2 was administered orally with Fe2O3NPs (5 mg/kg BW; >50 nm), group 3 was treated intraperitoneally with AgNPs (50 mg/kg BW; >100 nm) and group 4 was administered with the mixture of Fe2O3NPs with AgNPs. Animals were treated with doses every day for 79 days. The results showed that male rats treated with Fe2O3NPs, AgNPs and their combination showed significant (P <0.05) increase in the levels of cytokines (P53, TNF-α and IL-6) compared to control group. It was concluded that the combination of Fe2O3NPs, AgNPs group showed more reproductive toxicity than treatment with Fe2O3NPs or AgNPs alone.

Keywords: Iron oxide nanoparticles; Silver nanoparticles; Male rats; Cytokines.