Abstract

FORMULATIONS AND THEIR CHARACTERIZATION TO PATENT AND ADVANCEMENT OF SELF NANO-EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS)

K. M. Pooja Chaurasiya*, Pankaj Kumar Sharma and Vishwanath Agrahari

ABSTRACT

Background: The Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a novel drug delivery system utilized to enhance water dissolvability and bioavailability of poorly water-soluble drugs. Several challenges are still present in this approach which required more research. The prime aim of this review is to identify such challenges that can be improve in the future. Method: Through this review, we inform the recent patent and advancement in self-nanoemulsifying technology that used different type drug, excipient (oil, surfactant, co surfactant), instrument, and evaluation parameters. Result: SNEDDS has been found to possess great potential to improve the several issues related to poor bioavailability, site drug delivery, etc. In the past decade, SNEDDS approach has been complementarily used to solve the developed gripe, arisen from poorly soluble drugs. But this field still needs more attention to new discoveries. Conclusion: SNEDDS contributes a vital role in administration the different drug entities through a variety of route involving oral, topically etc. With solving the different issues. This review also confirms the significance of SNEDDS in safety, efficacy, and communal as well as the economic expense associated the healthcare.

Keywords: Self Nano-emulsifying Drug Delivery System, Pseudo Ternary Phase Diagram, Bioavailability, Poor Solubility, Permeability.