Abstract

LEFT VENTICULAR DIASTOLIC DYSFUNCTION BY TISSUE DOPPLER IN PATIENT WITH TYPE TWODIABETES MELLITUS

Dr. Hamzah Obaid Jeled Alkdsawi*

ABSTRACT

Background: Cardiovascular complications of diabetes are the main cause of mortality & morbidity in diabetic population. Asymptomatic Left venticular dysfunction is a common problem in this type of patients and require specific evaluation. Objectives: This study is designed to determine the frequency of LV diastolic dysfunction in patients with type 2 diabetes using conventional echocardiography and tissue Doppler imaging, and to evaluate the effect of different factors on this frequency. Methods: This study is a cross sectional study. It included 50 type 2 diabetics with negative cardiac history and 50 age and sex matched healthy control individuals. The sample of this study had been randomly selected from the patients attending the out patients clinic or admitted to the medical wards of Baghdad Teaching Hospital during the period from the 1st of January, 2012 to the 30th of June, 2012. Conventional echocardiography and tissue Doppler imaging had been performed on each patient. Results: This study revealed that diastolic dysfunction present in 16 patients (32% of the sample). Furthermore, none of the 3 patients who were younger than 40 year-old had diastolic dysfunction, compared to 7 out of 11 patients aging 60 year or older. It had been found that 11 out of 31 male patients and 5 out of 19 female patients had diastolic dysfunction, comprising 68.75% and 31.25% of those with diastolic dysfunction respectively. About 68.75% of the sample had diabetes for 5 years or more. this study showed that 13 out of 16 diabetic patients with diastolic dysfunction had un controlled diabetes in form of HbA1c level of 7% or more with a mean HbA1c level of 8.2+2.4%,compared to a mean of about 6.8+3.1% which had been observed in the group of diabetics with normal diastolic function this study showed that none of the 2 patients who were average in their weight had abnormal diastolic function ,compared to 2 out of 3 patients who had morbid obesity it had been found that the mean body mass index was 29.7+2.4 kg /m in the group of patients with diastolic dysfunction while it was 26.2+3.1 kg/m in the group of patients with normal diastolic function. Conclusion: Diastolic dysfunction is relatively frequent problem in asymptomatic type 2 diabetics. There is direct relationship between the age, duration of diabetes, HbA1c level and body mass index and the risk of having diastolic dysfunction.

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