Abstract

PROTECTIVE EFFECT OF A POLYHERBAL FORMULATION ON SERUM LIPIDS AND MARKER ENZYMES IN ISOPRENALINE HYDROCHLORIDE INDUCED CARDIOTOXICITY IN WISTAR RATS

P. Kavitha*

ABSTRACT

Cardioprotective potential of 70% ethanolic extract of a polyherbal formulation (PHF) containing the plants Allium sativum, Trigonella foenum-graecum and Linum usitatissimum on serum lipid profiles, myocardial marker enzymes in serum and heart homogenate in Isoprenaline hydrochloride (ISO) induced cardiotoxicity in rats were evaluated. Subcutaneous injection of ISO (25 mg/kg) to wistar rats showed a significant (p<0.05) increase in the levels of cholesterol, triglycerides, VLDL and LDL with significant decrease in the level of HDL. Increase in the levels of myocardial marker enzymes creatine kinase (CK), creatine kinase-MB, lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT) was seen in serum and the same concomitantly decreased in heart. Oral administration of polyherbal formulation -PHF (250 and 500 mg/kg) to Isoprenaline hydrochloride induced rats daily for a period of 28 days showed a significant improvement in lipid profile along with marker enzymes in serum and heart homogenate. From the study the effect of 500 mg/kg dose was more pronounced.

Keywords: Cardiovascular diseases, polyherbal formulation, herbal preparations, hypolipidemic activity, cardio protection.