Abstract

FORMULATION, DEVELOPMENT AND IN -VITRO EVALUATION OF FLOATING OSMOTIC DRUG DELIVERY SYSTEM FOR ADMINISTRATION OF AN ANTIHYPERTENSIVE DRUG

Kamakshi R.S. Kunkolienker*, Ajeet M. Godbole, Pankaj S. Gajare, Sandesh N. Somnache and Arti Pednekar

ABSTRACT

The purpose of the present research work is to formulate floating osmotic tablets of Metoprolol Succinate by swellable core technology and compression coating with floating layer to control the release of the drug by achieving zero order drug release kinetics and deliver it in the vicinity of its absorption site. Metoprolol Succinate is freely water-soluble antihypertensive agent which is absorbed mainly in the upper part of small intestine having a shorter biological half-life which makes it an ideal candidate for Gastro retentive and controlled drug delivery system. In the present study core tablets of Metoprolol Succinate were compressed along with the suitable osmotic agent with different grades of HPMC swellable polymers. The core tablets were coated with cellulose acetate polymer, using dibutyl phthalate as the plasticizer in acetone as the coating solvent. After drying the tablets were compression coated with HPMC K4M and sodium bicarbonate mixture which was used as the floating layer. Three orifices of 0.5 micrometre were drilled mechanically on the compression coated tablets. Based on the results obtained formulation F7 was chosen as the best formulation as it controlled drug release up to 14 hours by following zero order drug release profile.

Keywords: Floating, Osmotic, Swellable, Gastro-retentive, Metoprolol Succinate.