Abstract

DEVELOPMENT AND EVALUATION OF SOLID DISPERSION OF RANOLAZINE

Digeshwari Patel*, Aman Jaiswal, Basudha Singh Gautam and Pawan Devangan

ABSTRACT

The present research work aims to enhance the solubility parameter of ranolazine (RNZ) by using hydrophilic polymer via solid dispersion (SD) technique. Ranolazine has antianginal and anti-ischemic effects that do not depend upon reductions in heart rate or blood pressure. The solid dispersion of ranolazine was successfully prepared by the solvent evaporation method with a hydrophilic polymer such as hydroxypropyl methylcellulose (HPMC) and Polyvinyl pyrrolidone K-30 (PVP K-30) in 1:1, 1:1.5, 1:2, 1:2.5, 1:3 w/w (ranolazine: polymer) ratio. The prepared solid dispersions samples were characterized by fourier transform infrared spectroscopy, melting point, equilibrium solubility, drug content, and in vitro drug release. The solid dispersion was optimized by equilibrium solubility and the solubility of ranolazine was enhanced 3-fold with PVP K-30 (1:2) ratio and drug content are also found 93.63%. In vitro % drug release was found to be 94.5% in 120 min. The result indicated to enhance the solubility of ranolazine with PVP K-30 polymer.

Keywords: Ranolazine, Solid dispersion, Solubility enhancement, Angina pectoris.