Abstract

DESIGN, DEVELOPMENT AND EVALUATION OF POLYHERBAL ANTHELMINTIC SYRUP

Firdous Shaikh*, Yogesh Kolekar, Yogesh Katkar, Madhuri Dinde and Priyanka Bhosale

ABSTRACT

The aqueous extracts of the Musa paradisiaca leaves, ethanolic extract of Curcuma longa and aqueous syrup of Zingiber officinale were individually screened for their Anthelmintic activity by using adult earthworm. These extracts were first screened for their Anthelmintic activity by preparing different concentrations and then by using these key ingredients as API plus by adding some additive in it, the formulation was prepared. World Health Organization (WHO) estimate that a staggering two billion people harbour parasitic worm infections. Parasitic worms also infect livestock and crops, affecting food production with resultant economic impact. Regardless of this dominance of parasitic infections, the research on Anthelmintic drug is poor. As per WHO, only a few drugs are often used in the treatment of helminthes in human beings. Anthelmintics from the natural sources may play an important role in the treatment of these parasitic infections. In the view of this, the current investigation was carried out with the aim to prepare and evaluate the Anthelmintic activity of an herbal formulation. Three different batches of this formulation were prepared and then each batch was individually screened for Anthelmintic activity, the batch which shows optimum effect was selected for the preparation of final formulation. It was observed that the final formulation shows synergistic effect. The activity of this herbal formulation was checked against the marketed formulation, Albendazole tablet and surprisingly herbal formulation shown better effect than the marketed one. Finally, the herbal syrup was further explored for its evaluation tests.

Keywords: Musa paradisiaca, Curcuma longa, Zingiber officinale, Anthelmintic activity, Polyherbal syrup.