Abstract

FORMULATION AND CHARACTERIZATION OF TRANSDERMAL PATCH OF METOPROLOL

Mayuri Mote, Umashri Kokatnur*, Panchaxari Dandagi and Archana Patil

ABSTRACT

The polymers selected for sustaining the release of drug were HPMC K15 M and Eudragit RL 100. The patches were formulated using combination of polymers and PEG 400 as plasticizer. The transdermal patches were evaluated for their physicochemical properties. All the prepared formulations showed good physical stability. The ex vivo skin permeation studies were performed using Franz diffusion cell. The results followed the release profile of metoprolol followed mixed higuchi and peppas kinetic in different formulations. However, the release profile of the optimized formulation F2 (R2 = 0.9808 peppas) indicated that the permeation of the drug from the patches was governed by a diffusion mechanism. Based on the observations, it can be reasonably concluded that HPMC K15 M and Eudragit RL 100 polymers are better suited for the development of transdermal patches of Metoprolol. Out of all the formulated patches F2 showed good permeation in 8hrs. So F2 formulation was selected as best formulation.

Keywords: Transdermal patches, Metoprolol, HPMC K15 M, Eudragit RL 100, permeation enhancer, ex vivo skin permeation study.