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ROLE OF DIFFERENT DRUGLIKENESS FILTERS IN DRUG DESIGN
N. Ramalakshmi, S. Amuthalakshmi*, S. Arunkumar
ABSTRACT
Physicochemical properties play an important role in the pharmacokinetics, drug likeness and medicinal chemistry friendliness of small molecules. Drug likeness for a novel chemical compound is a very important property in drug design. In this manuscript, we have discussed various drug likeness filters (drug likeness rules) used in drug design. The significance of physicochemical properties were also discussed in detail. Keywords: Drug likeness, Swiss ADME, Lipinski rule of five, GHOSE Filter, VEBER Filter. [Download Article] [Download Certifiate] |