Abstract

ORGAN ON A CHIP AS MICROFLUIDIC CELL CULTURE TECHNIQUE

Hima C. S.*, S. S. Subin, Chitra C. Nair, Asheeta A., Fathima Beevi U. and Sandhya M. J. Nair

ABSTRACT

Organ on a chips are microfluidic cell culture technique that mimic the multicellular architecture, tissue-tissue interfaces and relevant physical microenvironment of key functional units of living organs, while providing dynamic vascular perfusion in vitro. They are called ‘chips’ because they were originally fabricated using methods adapted from those used for manufacturing of computer microchips. They essentially enable a synthetic biology approach to investigate mechanisms at the cell, tissue and organ levels. Organ on a chip aim to reproduce the function of biological organs or tissues as realistic models which helps in forming various specialised cells in organ on a chip. This include the skin on a chip, lung on a chip, heart on a chip, Kidney on a chip etc. They also had a wide range of application in Toxicology, Drug Discovery, in Cancer treatment, Antiaging etc.

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