Abstract

PRONIOSOMES - A CARRIER FOR NOVEL DRUG DELIVERY SYSTEM: A REVIEW

Nivya P.*, Dr. S. Daisy Chella Kumari, Dr. R. Devi Damayanthi, Ramya Selvam T. and Bhuvaneswari K.

ABSTRACT

Novel drug delivery system has emerged embracing various route of administration. Oral drug delivery is the most common and preferred method of drug administration. A lipid based drug delivery has become an emerging strategy for improved oral drug delivery of poorly soluble drugs. Drug encapsulation in the vesicles is one such system which helps to prolong drug duration in systemic circulation and decreases the toxicity. Based on this technique, a number of vesicular drug delivery system such as liposomes, niosomes and provesicular systems like proliposomes and proniosomes have been developed. Proniosomes, a dry formulation minimizes all such problems related to niosomes. These proniosomes are used to produce niosomes within minutes by the addition of hot water followed by agitation such as proniosomes derived niosomes are as good or even better than conventional niosome. Preparation of proniosomes was an optimized for highest percentage drug entrapment. Microscopy confirms that all particles are uniform in size and shape. The invitro release studies of drug from proniosome exhibited a prolonged release has studied over a period of 24 hours. In the stability study, it was observed that the drug leakage from vesicle was least at 4℃ followed by 37ºC. Proniosomes are meant for targeted drug delivery thereby reduces the toxicity associated with conventional dosage form.

Keywords: Proniosomes, Cholesterol, Maltodextrin.