Abstract

ANTIBIOTIC SUSCEPTIBILITY PATTERNS OF PSEUDOMONAS AERUGINOSA AT A TERTIARY CANCER CARE HOSPITAL IN SOUTH INDIA

Sravanthi CH, *Radha Rani and Swathi Nayani

ABSTRACT

Objectives: The present study aimed to monitor the antibiotic profile of Pseudomonas aeruginosa isolates from a tertiary care cancer centre in South India and to understand the antimicrobial susceptibility pattern of the organism from this geographical region and in this group of cancer patients. Materials and Methods: Between Jan 2018 to Dec 2018, two hundred and twenty one isolates of Pseudomonas aeruginosa were isolated from different clinical samples. The isolates identified by conventional methods and antimicrobial susceptibility pattern of all isolates were carried out by Kirby-Bauer disc diffusion method as per CLSI guidelines. Results: Most of the P. aeruginosa strains were isolated from clinical samples such as pus, urine, blood and sputum. Out of 221 isolates of P. aeruginosa from various clinical specimens Amikacin was the most sensitive agent with 87.6% susceptibility rate, followed by Meropenem and Imipenem with susceptibility rates of 84.3% and 83.01% respectively. Piperacillin-tazobactum showed a susceptibility rate of 82.6% as compared to Cefoperazone-sulbactum, which had a susceptibility rate of 79.9%. The susceptibility rate to Levofloxacin was 77.3% and to cefepime was 79.63%. Conclusion: Periodic antimicrobial susceptibility testing should be carried out to detect the resistance trends.Constant surveillance of antimicrobial resistance trends, administration of appropriate antibiotics, use of combination therapy and simple measures like hand washing will help in the control of this organism.

Keywords: Antimicrobial susceptibility, Kirby Bauer disc diffusion method, Antibiotic resistance, Pseudomonas aeruginosa.