Abstract

FORMULATION ASPECT AND DEVELOPMENT OF A HERBAL TRANSDERMAL PATCH FOR ANTICANCER THERAPY AND ITS PHARMACEUTICAL EVALUATION

Dr. Babita Agarwal*, Dr. Prasad Kadam, Irshad Jamadar, Apurva Deogaonkar

ABSTRACT

The Transdermal Drug Delivery System (TDDS) is the new routes for the systemic delivery of drugs through intact skin. A transdermal patch is a medicated patch placed on the skin to deliver medication through the skin into the bloodstream. The present investigation aimed to evaluate the possibility of using herbal extracts to develop transdermal delivery of ascorbic acid as an anti-cancerous drug. The investigation is also aimed at determining herbal drugs' potential as they are mostly non-toxic and have a beneficial effect on the body. The transdermal patches were formulated by the solvent casting method. Ascorbic Acid acts as a pro‐oxidant at pharmacological levels, delivering H2O2 to tumorous tissue upon oxidation and leading cell death. The prepared formulations were assessed for various parameters like thickness, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content. The herbal extract of ascorbic acid was assayed using the Brine Shrimp Lethality Assay method, which showed about 80-90% mortality. The study shows a new perspective on working with herbal drugs in pharmaceutics.

Keywords: Transdermal, anticancer, Ascorbic Acid, Matrix films.