Abstract

MODERN DRUG DELIVERY SYSTEMS FOR ORAL INSULIN DELIVERY IN DIABETES MELLITUS: A REVIEW

Rupal Dubey* and Eisha Ganju

ABSTRACT

Medicine research is based on the dogma that to cure a disease its cause must be thoroughly understood. The treatment of any disease lies on the correct diagnosis of its cause. Diabetes is one such disease that has been thoroughly understood and despite having a clear picture of its nearest cure i.e make insulin available orally, nothing promising yet has been achieved. Diabetes sets a perfect example of the importance and challenges in discovery of medicine for the ultimate cure. Type 2 diabetes mellitus (DM) is a chronic metabolic disorder in which prevalence has been increasing steadily all over the world. As a result of this trend, it is fast becoming an epidemic in some countries of the world with the number of people affected expected to double in the next decade due to increase in ageing population, thereby adding to the already existing burden for healthcare providers, especially in poorly developed countries. This review is based on a various approaches which could be used to deliver insulin orally to the patients. The forms may include nanoparticles, microspheres, intestinal patches, hydrogels, tablets and capsules.

Keywords: Diabetes Mellitus, Oral, Insulin, Polymer, Nanoparticles.