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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

SPECTROPHOTOMETRIC MICRO DETERMINATION OF MECLIZINE HYDROCHLORIDE IN THEIR PHARMACEUTICAL FORMULATIONS AND SPIKED PLASMA

Hamid M. Younis and Hany A. Omara*

ABSTRACT

proposed for the rapid determination of meclizine hydrochloride using bromocressol green (BCG) and bromophenol blue (BPB). The method consists of extracting the formed ion- associates into chloroform. The ion -associates exhibit absorption maxima at 417 and 412 nm for BCG and BPB, respectively. Meclizine HCl can be determined up to 2.6-25 and 2.5-17.5 μg/ml, using BCG and BPB, respectively. The effect of acidity, reagent concentration, time, solvent and stoichiometric ratio of the ion- associates were studied. The molar absorptivity and Sandell sensitivity of the reaction products were calculated. The method was applied to the determination of the drugs in their pure form or pharmaceutical preparations.

Keywords: Meclizine hydrochloride; Spectrophotometric; bromocressol green (BCG) and bromophenol blue (BPB); Pharmaceutical analysis.

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