Abstract

PREPARATION AND EVALUATION OF MICONAZOLE NITRATE TRANSFERSOMAL GEL TO ENHANCE SKIN PENETRATION AND INCREASE ANTIFUNGAL ACTIVITY

Sonam Upadhyaya, Brijesh K. Arjariya, R. S. Ghosh and Ravi Prakash Yadav*

ABSTRACT

The aim of present study to prepare and evaluate miconazole nitrate transfersomal gel to enhance skin penetration and increase antifungal activity. The selected research work was divided into three phases. The first phase comprised of selection of drugs and excipients, Preformulation studies, preparation, optimization and in vitro characterization of selected carriers, nanovesicular transfersome. Drugs selected were Miconazole Nitrate and nanovesicular carriers selected. In the second phase of work, preparation and characterization of transfersomal gel formulation containing selected novel carrier was carried out. In third phase, prepared delivery system was evaluated for in vitro studies to ensure the behavior of delivery system. Transfersomes are excellent drug carrier to permeate skin tissues. Embedding of transferosomal Miconazole Nitrate into gel improves permeation of the drug. Moreover, stability of transferosomal vesicles is improved when they are embedded into gel dosage form. Use of certain skin permeation enhancers with transferosomal Miconazole Nitrate gel is available and potentiates the permeation of the drug. This technique can serve as a potential tool for delivery of various topical drugs without altering the skin structure.

Keywords: Miconazole nitrate; Transfersomal gel; Antifungul; Preformulation; Preformulation.