Abstract

REVIEW ON UPDATED TREATMENT OF ACNE VULGARIS USING EMULGEL AS NOVEL FORMULATION APPROACH

*Mehvish Nagamia and Dr. Jigar Vyas, M.pharm, Phd.*Mehvish Nagamia and Dr. Jigar Vyas, M.pharm, Phd.

ABSTRACT

Propionibacterium acnes is an important target in acne management. Acne can persist for years and result in disfigurement and permanent scarring, and it can have serious adverse effects. Acne lesions are typically classified as non-inflammatory (open and closed comedones) or inflammatory (papules and pustules). Both topical and systemic agents may be employed for treatment of acne i.e. topical retinoid, oral antibiotics, hormonal therapy, Isoretenin and some other medications. Topical clindamycin reduces free fatty acid concentrations on the skin and suppresses the growth of propionibacterium acnes (corynebacterium acnes). Antibiotic resistance has increased, reducing its clinical efficiency. To overcome these problems and for better efficacy against the macrolide or clindamycin resistant P.acnes many combinational therapies and new formulation approach was studied treatment and underlined the benefit of a combination therapy with a topical retinoid such as adapalene and a topical antibiotic, Clindamycin and benzoyl peroxide, Zinc ascorbate and clindamycin shows the additive effect against the P.acnesin the treatment of inflammatory acne also had given an improved results. The topical applications of the drug offers the potential advantages of delivering the drug directly to the site of action and delivering the drug for extended period of time at the effected site that mainly acts at the related regions. The Emulgel had enhancing the topical delivery of drug, have several favourable properties for dermatological use such as being thixotropic, greaseless, easily spredable, easily removable, emollient, nonstaining, long shelf life, transparent and pleasing appearance. This review gives knowledge about the acne pathogenesis, causes, treatmentand formulation, preparation and characterization of emulgeland combinational drug therapy to provide effective at least dose amend drug release.

Keywords: Emulgel, Propionibacterium acne, Benzoyl peroxide, Clindamycin and Zinc ascorbate.