Abstract

ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF MILAGARANAI VER CHOORANAM (ROOT OF TODDALIA ASIATICA) IN RODENTS

A.Karthikeyan*, K.S.Sivasaravanan , I.S.Gnanavel, D.Prakash,V.Velpandian

ABSTRACT

Milagaranai Ver Chooranam(root of Toddalia asiatica)is one of the Siddha herbal drug, which has been indicated for its analgesic and antiinflammatory properties. The aim of this present study is to validate Analgesic, acute and chronic anti-inflammatory activity of Milagaranai Ver Chooranamat the doses of 100 mg/kg and200 mg/kgbody weight in experimental animals. Analgesic activity was evaluated by hot plate method in Swiss albino mice; acute and chronic anti-inflammatory activity was evaluated by carrageenaninduced paw oedema and cotton pellet granuloma in Wistar albino rats respectively. Diclofenac sodium and Ibuprofen were employed as reference drugs for analgesic and anti-inflammatory studies.The animals were randomized into 4 groups (n=6). Control group received vehicle only. MVC 100 and MVC200 significantly inhibited pain, carrageenan induced paw oedema and reduced the weight of cotton pellet granuloma. These effects are more significant at the dose of 200 mg compared to MVC 100mg dose level which showed the dose dependent activity of MVC.Our results confirm the traditional use of Milagaranai Ver Chooranam as an analgesic and anti-inflammatory.

Keywords: Analgesic, anti-inflammatory, carrageenan induced oedema, cotton pellet granuloma, Milagaranai Ver Chooranam, Siddha.