Abstract

FORMULATION AND EVALUATION OF PLANT EXTRACT GELS AS ANTI-ACNE: REVIEW ARTICLE

Laili Zirrahmi Ahad*, Rina Wahyuni and Salman Umar

ABSTRACT

Acne is a skin irritant that occurs due to blockage of the fabasea follicle due to dead cells, sebum, and inflammation caused by the Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus bacteria. In preparing this review article, literature studies were used to find sources in the form of books and journals (national, international) in the last 20 years (2000-2020). In an effort to treat acne, natural ingredients can be used. Formulation and evaluation of plant extract gels that have the potential to act as anti-acne are as follows: Portulaca Quadrifida, Carica papaya L., Berberis aristata, Luffa Acutangula, A. Spinosus and M. Alba, Azadirachta Indica, Allium Sativum, Acorus Calamus, Annona Squamosa and Chenopodium Album, M. Micrantha Kunth, R.cordifolia, Phoenix Sylvestris and Cuscuta reflexa. Generally, gel evaluation consists of homogeneity, color, pH, consistency, viscosity, spreadability, washability, and antibacterial activity testing. The gel as result of Acorus Calamus, Annona Squamosa and Chenopodium Album extracts combination has a strong inhibitory potential of 100 μg / ml (34 mm), 50 μg / ml (30mm), 25μg / ml (25mm) which is stronger than other formulations.

Keywords: Anti-acne, Extract, Gel evaluation, Gel formulation.