Abstract

THE CORRELATION OF C- REACTIVE PROTEIN VALUES WITH MALNUTRITION IN PATIENTS ON HAEMODIALYSIS (IN SINGLE CENTER STUDY)

*Dr. Mustafa K. Mohammed and Assistant Prof. Dr. Arif Sami

ABSTRACT

Background: Malnutrition and inflammation are common in hemodialysis patients, and are usually closely associated. Serum C-reactive protein (CRP) concentrations have been found to be significantly elevated in hemodialysis patients and reflects chronic inflammation, and as an acute-phase reactant, is a sensitive and an independent marker of malnutrition. Objective: To find the correlation of CRP values with malnutrition in patients with chronic kideny disease undergoing haemodialysis in Al-Kadhymia teaching hospital (dialysis unit). Patients and Methods: The study was performed in Al kadhymia Teaching Hospital from October 2012 to April 2013, by selecting 50 patients (mean age 50.94±14.93). The likely causes of renal failure were recorded. The nutritional status determined by various methods Anthropometry {weight(kg), height(m), body mass index(kg/m²) (BMI), triceps skin fold thickness (mm) (TSF), mid arm muscle circumference(cm)} and by Biochemical measures(Albumin, CRP, Creatinine, Urea, Na, Ca, Ph, Cl & K). Result: Males were 58% & females were 42% The mean age of the study population was 50.94±14.93 years, with no gender difference(P. value o.258) hypertensive nephropathy (38%), diabetes mellitus (20%) both were the main possible cause. There was significant difference between females(57%) and males(24%) patients regarding hypertension (p.value 0.017) According to CRP value there was significant difference between females lean group and others measured by TSF (p.value0.045). According to CRP values there was significant difference between females malnutrition group and others measured by BMI (p.value 0.044). there was no significant difference between CRP and s.albumin (p.value 0.266). Conclusion: We conclude that the acute phase response occurs in the majority of hemodialysis patients. A negative correlation between CRP and albumin reveales the existence of relationship between CRP and other inflammatory and nutritional factors like BMI and TSF.

Keywords: End-stage renal failure, hemodialysis, C-reactive protein, malnutrition-inflammation.