Abstract

ANTIOBESITY EFFECT OF MACROTYLOMA UNIFLORUM LEAVES EXTRACT ON RATS FED ON HYPERCALORIC DIET

V.Bharathi* and Dr.A.Vijaya anand

ABSTRACT

The present study was carried out to investigate the antiobesity effect of leaves extract of Macrotyloma uniflorum Linn in rats . Obesity was induced by administration of cholesterol for 40 days. The Macrotyloma uniflorum laves extract (at the tested doses of 200 and 400 mg/kg) exhibited a significant hypolipidemic effect and thus reduced the obesity. The body weight and feed intake was reduced significantly. Treatment of obese animals with the leaves extract of Macrotyloma uniflorum exhibited an increased in high density lipoprotein with a concomitant decrease in total cholesterol, triglycerides very low density and low density lipo protein. Thus the study indicates that the antiobesity activity of leaves extract of Macrotyloma uniflorum could be attributed to the presence of phyotoconstituent in the leaves and the tendency of the extract to reduce lipid profile .

Keywords: Macrotyloma uniflorum, leaves, phyotoconstituent