Abstract

FORMULATION AND IN-VITRO EVALUATION OF TINIDAZOLE EMULGEL FOR TOPICAL APPLICATION

Mr. Sitaram Kale, Miss. Sayali S. Chavan, Mrs. Pradnya Jagtap*, Mr. Kiran B. Aphale

ABSTRACT

Emulgel is the recent technology in novel drug delivery system used for control release of emulsion and gel for the purpose of topical use. The goal of the present study was to design and Characterization of Emulgel of an antiprotozoal Tinidazole drug to incorporate hydrophobic or poorly water soluble drug in formulation and delivered through gels and which will increase skin penetration of drug. Background: Formulation and in-vitro evaluation of tinidazole emulgel for topical application. Material and Methods: For the preparation of emulgel carbapol 940 is used as gelling agent which was soaked in water for24 hrs, and triehanolamine is added. Emulsion is prepared by mixing oil phase and aqueous phase at 70-80oC. with continuous stirring. Then emulsion is added into the el base for preparation of emulgel. Result and Conclusion: In the present study, an attempt has been made to formulate the topical drug delivery system of Tinidazole Emulgel. The F3 batch was found to be optimized formulation which was formulated by changing concentrations of excipients and showing good drug release.

Keywords: Tinidazole, Emulgel, Antiprotozoal, Carbapol940.