Abstract

RECENT ADVANCES OF SUSTAINED RELEASE ORAL DRUG DELIVERY SYSTEM: A REVIEW

Mohamed Zameeruddin, Hadbe Namdev*, Jadhav S.B., Kadam V.S.,Bharkad V.B., Bade Anil

ABSTRACT

The term “sustained release” is known to have existed in the medical and pharmaceutical literature for many decades. Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. The attractiveness of these dosage forms is due to awareness to toxicity and ineffectiveness of drugs when administered by oral conventional method in the form of tablets & capsules. The basic rationale of sustained release drug delivery system optimizes the biopharmaceutical, pharmacokinetic and pharmacodynamics properties of a drug in such a way that its utility is maximized, sideeffects are reduced and cure of the disease is achieved. There are various physiochemical and biological properties which affect the extended release drug delivery system. Extended release drug formulations have been used since 1960’s. Sustained Release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. This article provides information about the Sustain release formulation, Design and Fabrication of oral controlled release systems. The basic goal of sustained release is provide promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body and increase patient compliance by reducing frequency of dose

Keywords: Sustained Release, Oral controlled release, Matrix tablet, Patient compliance, Extend release.