Abstract

A STUDY ON THE EFFECT OF MILTEFOSINE DRUG ON NOTCH PATHWAY INDUCING APOPTOSIS IN HUMAN BREAST CANCER CELLS

Ranjana Singh*, Vivek Singh, Nimra Habib and Abbas Ali Mahdi

ABSTRACT

Breast cancer is one of the leading causes of cancer death in women, for this problem we still needs a new kind of drugs for the treatment, here in this study we had repurposed the miltefosine for the treatment of breast cancer. While on molecular domain Notch proteins play crucial roles in shaping cell fates such as proliferation, differentiation and apoptosis. Role of Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine mammary gland. However, it is not clear whether Notch signaling is frequently expressed and activated in breast cancers. From this study we had found that Notch signaling was over expressed and highly activated in breast cancer cell lines, on other side we had checked efficacy of miltefosine as anticancer molecule on (MCF-7, MDA-MB-231) breast cancer cell lines that leads to apoptosis. However the genomic & proteomics observations also indicated that miltefosine can downregulate the Akt, Notch (1, 2, 3, & 4) and thus, opening a new gateway to combat multi drug resistant conditions in breast cancer.

Keywords: Notch, Breast Cancer, Akt, Miltefosine.