Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL FILMS FOR THE MANAGEMENT OF PARKINSON’S DISEASE

Umesh Kumar Sharma U. K.* and Jisha Gopi

ABSTRACT

Parkinson's disease is a neurodegenerative disorder characterized by a multifactorial nature because of reduction in dopamine level in the human brain. The Parkinson's disease is expected to increase mostly due to a greater aging population. The challenge is to control the effective drug volume in a patient's body to attain therapeutic response during progressive stages of Parkinson's disease. To achieve the therapeutic goal various dosage form approaches are used to enhance the delivery of anti-Parkinson's disease drugs into the brain. In the present Investigation buccal films of Levodopa- Carbidopa combination was formulated as per 24 factorial design with various polymers and used for optimization of the process parameters During the investigation various formulation aspects such as, weight uniformity, size uniformity, Thickness uniformity, folding endurance, moisture content, swelling index surface pH, bioadhesive strength, in vitro drug content, in vitro permeation was studied. The buccal film was found to be novel delivery systems extremely important in increasing therapeutic efficacy and reducing unwanted complications in the treatment of Parkinson's disease.

Keywords: Levodopa, Carbidopa, Parkinson’s Disease, Buccal Film, Bioadhesive Film