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SILYMARIN MICROSPHERES AND ITS ANTIPROLIFERATIVE ACTION ON HUMAN PROSTATE ADENOMATOUS CANCER DU145 CELLS
M.KrishnaPillai*, N.Thirumoorthy
ABSTRACT
Silymarin a flavonoid from milk thistle(Silybum marianum) exhibits a variety of pharmacological actions, including anti-proliferative and apoptotic activities against various types of cancers in intact animals and cancer cell lines. This present study was aimed to formulate microspheric form of Silymarin by using various polymers like Chitosen, Pectin, Carbopol 934P, Ethyl cellulose, Eudragit RS100. Microspheres were successfully prepared by emulsion solvent evaporation and ionic cross linking method.The prepared microspheres were evaluated for various parameters like encapsulation efficacy, Keywords: Silymarin, Microspheres, Cytotoxicity, DNA Fragmentation, Anticancer [Download Article] [Download Certifiate] |