Abstract

EVALUATION OF ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF MIRABILIS JALAPA ON ETHANOL INDUCED GASTRIC ULCER IN ALBINO RATS

Lakshmana Ganta*, Rajesh Kumar Dogiparthi, Prathap Reddy Pulusu, Sai KrishnaVallela, Mani Kumar Andugula, Dr.R.Srinivasan

ABSTRACT

The human gastrointestinal tract (GI tract) is an organ system responsible for consuming and digesting foodstuffs, absorbing nutrients, and expelling waste.The tract is commonly defined as the stomach and intestine, and is divided into the upper and lower gastrointestinal tracts. The upper gastrointestinal tract consists of the mouth,pharynx, esophagus, stomach, and duodenum. The lower gastrointestinal tract includes most of the small intestine and all of the large intestine. The term peptic ulcer refers to a break in the surface lining of the stomach or duodenum which is deep enough to produce a shallow crater (ulcer) in its wall.Mirabilis jalapa is also known as Four o'clock flower, marvel of Peru, beauty-of-the-night.the main chemical constituents include Eight betaxanthins (indicaxanthin, vulgaxanthin-I, miraxanthin-I, -II, - III, -IV, V and -VI) can be isolated from M. jalapa flowers. Rotenoids (mirabijalone A, B, C ans D, 9-O-methyl-4-hydroxyboeravinone B, boeravinone C and F, and 1,2,3,4-tetrahydro-1- methylisoquinoline-7,8-diol) can be isolated from the roots.Ethanol induced ulcer model was selected for assessing anti ulcer activity in rats.Omeprazole was used as standard drug.The parameter studied was ulcer index. Acute toxicity study was performed for Ethanolic extract of leaves of Mirabilis jalapa.

Keywords: Peptic ulcer, Mirabilis jalapa, Nyctaginaceae, Ethanol induced ulcer and omeprazole.