Abstract

FILM FORMING TRANSEMULGEL- A NOVEL DRUG DELIVERY SYSTEM

Parul Nigam*, Dr. Ajay K. Gupta, Dr. Akhilesh Vats

ABSTRACT

Transemulgel is a novel approach that could offer an alternative to traditional dosage form used on the skin like ointments, creams, gels and patches. The polymeric formulation is applied as a liquid to the skin and by solvent evaporation it forms an almost invisible in vitro film. Transdermal and dermal drug delivery system can provide some advantageous results over traditional dosage forms, such as minimizing first-pass metabolism in the GIT and liver, increasing bioavailability of drugs, the dose frequency, and strengthening drug delivery profile. The aim of this study was to identify alternatives to traditional dosage forms to minimize skin irritation, boost skin adhesion properties, increase drug release and patient acceptability from aesthetic point of view. Because of their extraordinary rheological behavior, transemulgel are advantageous in terms of ease of preparation, application, surface adhesion and ability to supply a wide variety of drugs.

Keywords: Transemulgel, Transdermal drug delivery system, Polymeric formulation, etc.