Abstract

INTERACTOME BETWEEN GENES AND DYSBIOSIS IN PERIODONTAL INFLAMMATION

Dr. J. Sanjusaviyapriya*, Dr. Y. Pradeep Kumar

ABSTRACT

Periodontitis is a infectious inflammatory disease. Various predisposing factors plays a major role in periodontitis. One of the predisposing factor is gene-microbial interaction.[1] There are two models have been proposed to explain this genetics-associated dysbiosis. In the first model, single nucleotide polymorphism variants may compromise genes that are associated with pathways of bacterial sensing and recognition. In the second model, the variant-affected genes lead to an excessive inflammatory environment in the subgingival niche, which favors the growth of specific biofilm bacteria. The increased production of gingival crevicular fluid caused by a hyperinflammatory response provides nutrients for plaque bacteria. So here we build an Interaction network between genes in subgingival bacterial inflammation[2]

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