Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VALSARTAN

Krushna Nina Lokhande and Dr. Bharat Vijaykumar Jain*

ABSTRACT

The main aim of present work was to formulate and evaluate sustain release matrix tablets of Valsartan, an angiotensin II Receptor type 1 antagonist. Sustain release formulation are those which delivers the drug locally or systemically at a predetermined rate for a fixed period of time. The powder mixtures were subjected to various pre-compression parameters such as angle of repose, bulk density, tapped density and Carr‟s index shows satisfactory result and the compressed tablets are evaluated for post-compression parameters such as weight variation, thickness, hardness, friability, drug content, in-vitro dissolution and stability studies. In-vitro dissolution studies were carried out for 24 hours using 0.1 N HCL for first 2 hours and pH 6.8 phosphate buffer for 24 hours and the result showed that formulations F4 and F7 showed good dissolution profile to control the drug release respectively. Formulation containing higher concentration of chitosan and sodium alginate along with polymers sustained the drug release for the period of 24 hours. The compatibility of the drug, polymers and other excipients were determined by FT-IR Spectroscopy. Results showed that the drug was compatible with polymers and other excipients. The release data was fitted to various mathematical models such as Zero-order, First-order, Higuchi equation and Korsmeyer-Peppas model to evaluate the kinetics and the drug release. The stability studies were carried out for 3 months and result indicates that the selected formulations (F4 and F7) were stable.

Keywords: Carbopol 934P, Chitosan, sodium alginate, sustain release matrix tablet, Valsartan.