Abstract

FORMULATION AND EVALUATION OF NANOSTRUCTURED LIPID CARRIERS FOR ORAL DELIVERY OF RUTIN

Sampath B. S.* and V. Felix Joe

ABSTRACT

Nano structured lipid carriers are used to deliver lipophilic drugs to enhance the oral bioavailability. The present study is aimed at utilizing the potential of nanostructured lipid carriers for improvement in oral bioavailability of Rutin. Nanostructured lipid carriers of rutin was prepared by hot melt microemulcification method. The hot melt was prepared by heating the drug with a blend of solid lipid and liquid lipids: Oleic acid and paraffin wax/bees wax is used as solid lipid and liquid lipids. The formulations were characterized for entrapment efficiency, drug content, particle size, zeta potential and In vitro drug studies. Stability studies were carried out as per ICH guidelines. The particle size analysis showed the average particle size of 550 nm for FB and FF formulations of rutin. The PDI value remained approximately around 0.600 indicated good dispersion of uniformly sized NLC’s. All the formulations followed Korsmeyer-peppas model of release profile. The DSC thermograms for the drug and formulations indicated that the drug was in crystalline form in the NLC. The FT-IR spectra showed no change in the signal peaks and thus indicated no interaction between the drug and the excipients. Stability studies indicated that no significant changes in the drug content and in vitro drug release, after a period of 4 weeks.

Keywords: Rutin, nanostructured lipid carriers, hot melt micro emulsification method, In vitro drug release and stability studies.