Abstract

STUDIES ON THE RELEASE OF NEBIVOLOL HYDROCHLORIDE FROM MATRIX PATCHES

Tripti Halder*, Bijit Saha, Bikramaditya Chowdhury Rajan R., Arunabha Nanda

ABSTRACT

Matrix type transdermal drug delivery systems containing Nebivolol hydrochloride were prepared using eudragit RL 100 as the base polymer with plasticizer (DBP/TBC/ATEC/ATBC) and chemical enhancer (n-Octanol/ IPM) by solvent evaporation technique. Physiochemical parameters were characterized and in-vitro release from formulation film was performed. On the basis of release data, invitro permeation studies of selected patches were performed by using modified Franz diffusion cell through mice skin. The FT-IR study showed no polymer drug interaction. The release from the patches mainly followed the zero order kinetics. DBP and ATEC are best choice of plasticizers. Two formulations were the preferred choices for preparing the matrixes.

Keywords: Nebivolol Hydrochloride; Transdermal Matrix Patches; Hypertension; Kinetic Models.