Abstract

SYNTHESIS AND BIOLOGICAL SCREENING OF 3, 5-DIARYL-1- PHENYL-2-PYRAZOLINES AS ANTI-INFLAMMATORY AGENTS

*Mahesh. D. Bhanushali¹, Shivkumar. M. Hipparagi ², Suhas. A. Patil³, Sudhir. N. Sambrekar⁴.

¹Department of Pharmaceutical Chemistry, Maratha Mandal’s College of Pharmacy, Belgaum. India.
²Department of Pharmaceutical Chemistry, KLE University’s, College of Pharmacy, Rajajinagar, Bangalore-40.
³Department of Pharmacognosy, Maratha Mandal’s College of Pharmacy, Belgaum.
⁴Department of Pharmacology, Maratha Mandal’s College of Pharmacy, Belgaum.

ABSTRACT

In the present study a new series of 3, 5-diaryl-1-phenyl-2-pyrazoline were synthesized. Chalcones were synthesized by treating various substituted acetophenone with different substituted aromatic aldehydes in the presence of ethanol and sodium hydroxide solution. The pyrazoline derivatives were synthesized by cyclocondensation of chalcones with phenyl hydrazine. The structures of the synthesized compound have been established on the basis of IR and 1HNMR data. The compounds were screened in-vivo for their anti-inflammatory activity by using carrageenan induced rat paw edema method. Compounds P4, P7, P8 , P10 have shown maximum anti-inflammatory activity.

Keywords: Chalcones, Pyrazoline, Anti-inflammatory